“Prediction and Characterization of Protein-Protein Interfaces that Bind Intrinsically Disordered Protein Regions”, by Eric Wong, doctoral candidate, Gsponer Lab.
Thursday, November 28, 2019 12:30-3:30 pm, Room 203, Graduate Student Centre, 6371 Crescent Road.
Abstract:
Protein–protein interactions mediated by intrinsically disordered regions (IDRs) are differentiated from classical interactions between folded domains in terms of structure and function. Therefore, we developed a computational method specifically for the prediction of IDR-binding sites on the structures of folded domains. I will also discuss characteristics of IDR interactions, including localization patterns of disease and benign mutations that highlight the functional importance of IDR interactions.