March 27, 2025 at 3 to 4 PM in LSC 3 and Zoom
Hypoxic Pulmonary Hypertension and Sex-linked Protection by Endothelial Cell Caveolin-1
Dr. Richard Minshall, PhD, Professor of Anesthesiology, Pharmacology, and Bioengineering, College of Medicine, University of Illinois – Chicago
Professor Minshall is an established UIC principal investigator with 25 years of research, teaching, and service activity, continuous NIH funding, and over 200 primary publications and book chapters (h-index, 67). His research focuses on understanding the cellular signaling mechanisms that regulate vascular homeostasis, and how disruption of “normal” contributes to cardiovascular, cerebrovascular, and pulmonary vascular disease. The focus of his lecture will be on caveolin-1 (Cav-1) regulated signaling in the lung and the potential mechanisms by which depletion of Cav1 promotes pulmonary vascular remodeling and exacerbates hypoxia-induced pulmonary artery hypertension (PAH). The objective of this effort is to determine why PAH is more common in females, and why males tend to have a worse outcome. Sex-linked profiles of lung and heart function and gene expression in wild-type B6, Cav1-/-, and EC-specific Cav-1 reconstituted Cav1-/- mice (EC-Cav1-RC), as well as preliminary scRNAseq-defined lung cell populations in wild-type and inducible EC-specific Cav1-/- male and female mice exposed to normoxia vs hypoxia will be discussed.