“New modalities for interfering with outer membrane biogenesis in Gram-negative bacteria”, by Steven Rutherford, Senior Scientist, Infectious Disease, Genentech. Abstract: Multi-drug resistant bacteria are a global health threat and new strategies are needed to combat them. However, the discovery of novel antibiotics to treat infections by Gram-negative bacteria has been thwarted by the outer membrane, […]
“Making heads or tails of Mediator function, and how transcription start sites earn their STRIPEs”, Gabriel Zentner, Assistant Professor, Department of Biology, Indiana University Bloomington. Precise transcriptional regulation is critical for diverse aspects of biology ranging from cellular differentiation to metabolic homeostasis, and transcription is frequently deregulated in human disease. We use genome-wide approaches to […]
“Differential roles for DNAJ isoforms in HTT-polyQ and mutant FUS aggregation modulation revealed by chaperone network screens”, by Reut Shalgi, Assistant Professor, Rappaport Faculty of Medicine, Technion, Israel Institute of Technology. Abstract: Protein aggregation is a hallmark of many neurodegenerative diseases. In order to cope with misfolding and aggregation, cells have evolved an elaborate network […]
“Comparative epigenomics determines transcriptional regulatory codes in mammalian genomes,” by Jennifer Mitchell, Department of Cell and Systems Biology, University of Toronto. Abstract: Non-coding transcriptional enhancers are critical for development, phenotype divergence during evolution and often mutated in disease contexts; however, even in well-studied cell types, the sequence code conferring enhancer activity remains unknown. Enhancers are […]
‘Tis the season to wish one another joy, love, and peace from a social distance. Happy holidays and have a wonderful New Year! Biochemistry and Molecular Biology office will be closed from noon Thursday, December 24, 2020 and will re-open Monday, January 4, 2021.
BMBDG Seminar – Steven Rutherford
BMBDG Seminar – Gabriel Zentner
BMBDG Seminar – Reut Shalgi
BMBDG Seminar – Jennifer Mitchell
Fabian Garces – Doctoral Exam
Happy Holidays