Zoom Presentations – Monday, August 10, 2020 at 2:30 pm Andrew Alexander – “Understanding Staphylococcus aureus β-lactam resistance: a structural investigation.” Methicillin-resistant Staphylococcus aureus (MRSA) infections increase mortality and morbidity worldwide, threatening public health. MRSA is resistant to many classes of antibiotics including the most commonly prescribed β-lactam antibiotic class, making treatment of infections difficult. In […]
“Structural Characterization of the Bacterial Injectisome,” by Dorothy Majewski, PhD Candidate, Strynadka Lab. Abstract: The injectisome is a syringe-like protein complex essential for the virulence of many Gram-negative pathogenic bacteria. As a potential target for drug and vaccine design, studies to elucidate its structure have been ongoing over the past two decades. Two components of […]
2020 Astell Award – Presentation to Katie Gyte and Laura Meleady. Join us for the presentation of the 2020 Astell Award for trainee activities promoting Equity, Diversity and Inclusion (EDI). The short award presentation will be followed by the BMB research seminar. “Structure-guided antimicrobial discovery using a hybrid atomic toolbox,”by Dr. Natalie Strynadka, Professor, […]
“Three-Dimensional Transmission and Scanning Electron Microscopy of Molecular and Cellular Structures,” by Brian Caffrey, Candidate Subramaniam Lab. Abstract: Unravelling the complex spatial arrangement of networks and interfaces between proteins, cells and tissues is fundamental to our understanding of healthy and pathological processes. Therefore, a three-dimensional ultrastructural understanding of this arrangement is key to developing […]
“The interactive behaviour of white-collar workers in biological systems.” by Dr. Joerg Gsponer, Biochemistry and Molecular Biology, Michael Smith Laboratories, UBC. Monday, October 19, 2020 at 2:30 pm. Join by Zoom. Hosted by Dr. Leonard Foster
“New modalities for interfering with outer membrane biogenesis in Gram-negative bacteria”, by Steven Rutherford, Senior Scientist, Infectious Disease, Genentech. Abstract: Multi-drug resistant bacteria are a global health threat and new strategies are needed to combat them. However, the discovery of novel antibiotics to treat infections by Gram-negative bacteria has been thwarted by the outer membrane, […]
“Making heads or tails of Mediator function, and how transcription start sites earn their STRIPEs”, Gabriel Zentner, Assistant Professor, Department of Biology, Indiana University Bloomington. Precise transcriptional regulation is critical for diverse aspects of biology ranging from cellular differentiation to metabolic homeostasis, and transcription is frequently deregulated in human disease. We use genome-wide approaches to […]
Fall graduation 2020 for UBC, Vancouver will be a virtual ceremony. Pre-show celebration begins at 2:30 pm. Ceremony begins at 3:00 pm. Congratulations to our students!!! Grad students obtaining their degrees this fall: Linda Dumalo, MSc Jasmine Li-Brubacher, MSc John Andrew Alexander, PhD Brian James Caffrey, PhD Nathanael Caveney, PhD Chloe Gerak, PhD Kathleen Kolehmainen, […]
“Differential roles for DNAJ isoforms in HTT-polyQ and mutant FUS aggregation modulation revealed by chaperone network screens”, by Reut Shalgi, Assistant Professor, Rappaport Faculty of Medicine, Technion, Israel Institute of Technology. Abstract: Protein aggregation is a hallmark of many neurodegenerative diseases. In order to cope with misfolding and aggregation, cells have evolved an elaborate network […]
“Comparative epigenomics determines transcriptional regulatory codes in mammalian genomes,” by Jennifer Mitchell, Department of Cell and Systems Biology, University of Toronto. Abstract: Non-coding transcriptional enhancers are critical for development, phenotype divergence during evolution and often mutated in disease contexts; however, even in well-studied cell types, the sequence code conferring enhancer activity remains unknown. Enhancers are […]