Professor
Biochemistry and Molecular Biology
Faculty of Medicine
CIHR Post-Doctoral Fellow, Pennsylvania State University, 2003
University of Victoria, 1998, PhD
University of Victoria, 1992, BSc
phone: 6048226297
Lab Phone
6048223427
Life Sciences Centre, Office 5509
2350 Health Sciences Mall
Vancouver, BC V6T 1Z3
Canada

In multicellular organisms, the unique transcriptional program executed by each cell determines cellular identity. Indeed aberrant gene expression is a causal factor in many common human diseases, including cancer. While the availability of appropriate transcriptional activators or repressors determines whether a gene is transcribed, alteration of chromatin structure plays an important role in maintaining gene expression states. Chromatin is a nucleoprotein structure, consisting of DNA, histones, and non-histone proteins, which packages DNA in the eukaryotic nucleus. Our research uses a combination of molecular biology and bioinformatics to study the roles played by histones, histone chaperones, histone variants, and histone post-translational modifications in preserving active gene expression patterns. 

Comprehensive List 

Selected Publications