Within the Department I am responsible for the 4th year laboratory courses (BIOC 420 and 421), a 4th year lecture course on biochemical techniques (BIOC 404) as well, I oversee the administration of 4th year projects within the Department (BIOC 448 and 449).
The 4th year lab and lecture courses focus on developing strong laboratory skills as well as provide a solid foundation in methods of biochemistry experimentation. The content of these courses is in constant evolution reflecting the development of new research techniques and approaches. The aim of these courses is to provide students skills to enter into graduate school or a career in research.
My research interests relate to the clustering of metabolic disorders that collectively make up the metabolic syndrome, which is the association of several diseases including diabetes, obesity, hypertension and cardiovascular disease. Although these diseases are complex metabolic disorders that are influenced by multiple genetic and environmental factors, certain hormones appear to be involved in the association of these diseases. Among these hormones, I have a particular interest in insulin and the adipose derived hormone leptin. The underlying theme of my research is to study at the organism, cellular and molecular levels the mechanism of development as well as the consequences of dysregulated leptin and insulin signalling.
Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD. A Role for Hepatic Leptin Signaling in Lipid Metabolism via Altered VLDLD Composition and Liver Lipase Activity. Hepatology 57(2): 543-554, 2013
Levi J, Huynh FK, Denroche HC, Neumann UH, Glavas MM, Covey SD, Kieffer TJ. Hepatic Leptin Signalling and Subdiaphragmatic Vagal Efferents Are Not Required for Leptin-Induced Increases of Plasma IGFBP-2 in ob/ob Mice. Diabetologia 55(3): 752-762, 2011.
Arena ET, Auweter SD. Antunes LC, Vogl AW, Han J, Guttman JA, Croxen MA, Menendez A, Covey SD. Borchers CH. Finlay BB. The deubiquitinase activity of the Salmonella effector, SseL, prevents accumulation of cellular lipid droplets. Infection and Immunity (79)11: 4392-4400, 2011.
Denroche HC, Levi J, Wideman RD, Sequeria RM, Huynh FK, Covey SD , Kieffer TJ. Leptin Therapy Reverses Hyperglycemia in Streptozotocin-Diabetic Mice Independent of Hepatic Leptin Signaling. Diabetes 60(5):1414-1423, 2011.
Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD , Kieffer TJ. Disruption of Hepatic Leptin Signaling Protects Mice from Age- and Diet-Related Glucose Intolerance.Diabetes 59(12): 3032-3040, 2010.
Gray SL, Donald C, Jetha A, Covey SD , Kieffer TJ. Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic b -cell Signaling. Endocrinology 151(9): 4178-4186, 2010.
Wideman RD , Gray SL, Covey SD , Webb GC and Kieffer TJ. Transplantation of PC1/3-expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Molecular Therapy 17:191-198, 2009.
Wideman RD , Covey SD , Webb GC, Druker DJ, Kieffer TJ. A Switch from Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted Alpha-cells is accompanied by Differential Processing and of Proglucagon and Improved Glucose Homeostasis in Mice. Diabetes . 56: 2744-2752, 2007.
Covey SD , Brunet RH, Gandhi SG, McFarlane N, Boreham DR, Gerber GE, Trigatti BL. Cholesterol Depletion Inhibits Fatty Acid Uptake without Affecting CD36 or Caveolin-1 Distribution in Adipocytes.Biochemical Biophysical Research Communications . 355(1): 67-71, 2007.
Covey SD , Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SR, Kieffer TJ. The Pancreatic b -cell is a Key Site for Mediating the Effects of Leptin on Glucose Homeostasis.Cell Metabolism . 4(4): 291-302, 2006.
Lam NT, Covey SD , Lewis J, Oosman S, Webber T, Hsu EC, Cheung AT, Kieffer TJ. Leptin Resistance Following Over-expression of Protein Phosphatase 1B in Liver. Journal of Molecular Endocrinology. 36(1): 163-174 , 2006.
Trigatti B, Covey S , Rizvi A. SR-BI in HDL metabolism, atherosclerosis and heart disease: Lessons from gene-targeted mice. Biochemical Society Transactions . 32(1):116-120, 2004.
Covey SD , Krieger M, Wang W, Penman M, Trigatti BL. Scavenger Receptor Class B Type I-Mediated Protection Against Atherosclerosis in LDL Receptor-Negative Mice Involves its Expression in Bone Marrow-Derived Cells. Arteriosclerosis Thrombosis and Vascular Biology. 23(9):1589-1594, 2003.