My primary teaching role is to run the two-4th year laboratory courses Advanced Biochemical Techniques (BIOC 420) and Recombinant DNA Techniques (BIOC 421). The 4th year lab courses focus on developing strong laboratory and experimentation skills. The content of these courses is in constant evolution reflecting the development of new research techniques and approaches. The aim of these courses is to provide students the skills to enter graduate school or a career in research.
In addition, I oversee the project-based courses Directed Studies (BIOC 448) and Honours Thesis (BIOC 449). I am also an advisor for 4th year students and Honours Biochemistry programs.
My research interests are in the field of metabolism, with a particular focus on the altered metabolic states associated with obesity, diabetes, and cardiovascular disease. Most of my research is aimed at understanding the role of the hormone leptin in influencing metabolic pathways at the organism, cellular and molecular levels.
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S. Pereira, D. L. Cline, M. M. Glavas, S. D. Covey, T. J. Kieffer Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism. (2021) Endocrine Reviews. 42, 1–28.
S. D. Covey An adaptable dry lab for SYBR based RT-qPCR primer design to reinforce concepts in molecular biology and nucleic acids. (2021) Biochemistry and Molecular Biology Education. 49, 262-270.
S. D. Covey Reimagining learning outcomes to teach laboratory courses without a lab. (2020) Biochemistry and Molecular Biology Education. 48, 469–470.
S. Pereira, S. M. O’Dwyer, T. D. Webber, R. K. Baker, V. So, C. E. Ellis, et al. Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues. (2019) Scientific Reports. 9, 3307-3324.
U. H. Neumann, J. S. S. Ho, M. Mojibian, S. D. Covey, M. J. Charron, T. J. Kieffer Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival. (2016) Molecular Metabolism. 5, 731–736.
U. H. Neumann, H. C. Denroche, M. Mojibian, S. D. Covey, T. J. Kieffer Insulin knockout mice have extended survival but volatile blood glucose levels on leptin therapy. (2016) Endocrinology. 157, 1007–1012.
M. M. Kwon, S. M. O’Dwyer, R. K. Baker, S. D. Covey, T. J. Kieffer FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1. (2015) Cell Reports. 13, 1521–1527.
H. C. Denroche, M. M. Kwon, W. L. Quong, U. H. Neumann, J. E. Kulpa, S. Karunakaran, et al. Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol. (2015) Diabetologia. 58, 1100–1108.
A. M. D’Souza, A. Asadi, J. D. Johnson, S. D. Covey, T. J. Kieffer Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis. (2014) Endocrinology. 155, 1268–1279.
U. H. Neumann, S. Chen, Y. Y. C. Tam, R. K. Baker, S. D. Covey, P. R. Cullis, et al. IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. (2014) Endocrinology. 155, 716–725.
G. Romain, S. Tremblay, E. T. Arena, L. C. M. Antunes, S. Covey, M. T. Chow, et al. Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis. (2013) BMC Microbiology. 29, 543-545.
F. K. Huynh, U. H. Neumann, Y. Wang, B. Rodrigues, T. J. Kieffer, S. D. Covey A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. (2013) Hepatology. 57, 543–554.
J. Levi, F. K. Huynh, H. C. Denroche, U. H. Neumann, M. M. Glavas, S. D. Covey, et al. Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. (2012) Diabetologia. 55, 752–762.
E. T. Arena, S. D. Auweter, L. C. M. Antunes, A. W. Vogl, J. Han, J. A. Guttman, et al. The Deubiquitinase Activity of the Salmonella Pathogenicity Island 2 Effector, ssel, Prevents Accumulation of Cellular Lipid Droplets. (2011) Infection and Immunity. 79, 4392–4400.
H. C. Denroche, J. Levi, R. D. Wideman, R. M. Sequeira, F. K. Huynh, S. D. Covey, et al. Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. (2011) Diabetes. 60, 1414–1423.