The overarching mission of our research program is focused on exploring frontiers in structural biology and drug design using cryo electron microscopy (cryo-EM), with the central goal of accelerating the development of effective therapeutic agents. We take an interdisciplinary approach to this problem by combining novel technologies for 3D imaging with computation and machine learning as well as cell and molecular biology.
For more information on our Program please visit: https://electron.med.ubc.ca/.
- Subramaniam, S., Kleywegt, G.J. A paradigm shift in structural biology Nature Methods 19(1), 20-23. (2022 Jan 11)
- Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Tuttle KS, Marquez C, Sekirov I, Subramaniam S. SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex Science 10.1126/science.abn7760. (2022 Jan 20)
- Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Kim A, Li W, Dimitrov DS, Subramaniam S. Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding Cell Reports 37(12):110156. (2021 Dec 21)
- Zhu, X, Clarke, R, Puppala, AK, Chittori, S, Merk, A, Merrill B.J, Simonovic, M, Subramaniam, S. Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9 Nat Struct Mol Biol. 26(8):679-685. (2019)
- Chittori, S, Hong, J, Saunders, H, Feng, H, Ghirlando, R, Kelly, AE, Bai, Y, Subramaniam, S. Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N
- Science 359(6373), 339-343. (2018)