BMBDG Seminar: Dr. Gerd Prehna – November 07, 2022 at 2:30 pm

Title: Versatility of the type VI secretion system.

Assistant Professor. Department of Microbiology.

University of Manitoba

Abstract: Type VI secretion systems (T6SSs) are dynamic nanomachines that Gram-negative bacteria use for numerous biological functions including killing competing bacteria and pathogenesis. Bacteria use the T6SS to deliver protein effectors into adjacent cells to kill rivals and establish niche dominance. In the evolutionary arms race of potent toxic effectors, the T6SS has been adapted to both secrete effectors directly into the periplasm of a prey-cell, and to secrete membrane proteins that target a toxin to the prey-cell cytoplasm. Using the Salmonella T6SS as a model system, our lab is studying the versatility of both T6SS effector secretion and function. Current research is focused on revealing the molecular mechanism of chaperone mediated membrane protein secretion by the T6SS and characterizing the biochemistry of the unique effectors that allow Salmonella serovars to outcompete the host microbiome.

Monday, November 07, 2022 at 2:30 pm at LSC 3 and Zoom

Hosted by: Dr. Natalie Strynadka