The University of British Columbia
UBC - A Place of Mind
The University of British Columbia
Faculty of MedicineDepartment of Biochemistry & Molecular Biology
  • Home
  • About
    • History
    • Directory
    • News
    • Newsletter
    • Alumni
    • BIOCAPS Spotlight
    • Contact us
  • Faculty and Research
    • Faculty
    • Faculty by Research Areas
  • Undergraduate
    • Prospective Students
    • Current Students
    • Courses
    • Advising
  • Graduate
    • Prospective Students
      • Living in Vancouver
      • Biochemistry Graduate Program Statistics
    • Program Information
    • Current Students
    • BMB-GSA
  • Postdocs
    • Post Doctoral Fellow Award
    • BMB Postdoctoral Scholar Program 
  • Seminars & Events
  • Resources
    • Documents
    • Faculty Onboarding
    • Postdoctoral Fellows Onboarding
    • Research Associates Onboarding
    • IT Support
  • EDI
  • Careers
» Faculty of Medicine » Home » BMBDG Seminar – Dr. Kevin A. Morano

BMBDG Seminar – Dr. Kevin A. Morano

Posted on March 3, 2021

Title: “Chaperone-mediated mechanisms of cellular proteostasis”

Dr. Kevin A. Morano, Professor, Department of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston

Abstract: A broad range of major diseases ranging from diabetes to neurodegenerative disorders including Alzheimer’s (AD), Parkinson’s (PD) and Huntington’s (HD) diseases have been linked to protein misfolding and aggregation. Protein homeostasis (proteostasis) in the cytosol and nucleus is maintained by networks of factors that promote protein folding (molecular chaperones) or clearance of terminally misfolded substrates (ubiquitin-proteasome system (UPS), autophagy).  Cells grow and proliferate under the constant threat of intrinsic and extrinsic proteotoxic stressors including reactive oxygen species (ROS), exogenous oxidants and reactive electrophiles. However, the interface between proteostasis and cellular reduction-oxidation (redox) buffering pathways, including the thioredoxin and glutathione systems, is not well understood. The long-term goal of my laboratory is a comprehensive understanding of the biological roles of cytoprotective chaperones, the machinery employed to maintain redox balance and the interplay between them. These studies employing tractable model systems will in turn guide future development of therapeutic interventions targeting ROS- and protein quality control-based disorders.

Monday, May 10, 2021 at 2:30 pm. Join by Zoom.

Hosted by Dr. Thibault Mayor

 

 

Read More | No Comments

  • Previous
  • Next
Department of Biochemistry & Molecular Biology
Faculty of Medicine
Life Sciences Centre
2350 Health Sciences Mall
Vancouver, BC Canada V6T 1Z3
Website biochem.ubc.ca
Find us on
 
Back to top
The University of British Columbia
  • Emergency Procedures |
  • Terms of Use |
  • Copyright |
  • Accessibility