Title: Blood clot stability can be controlled using lipid nanoparticle-delivered siRNA
Abstract: Disruptions in the balance of clot formation and degradation can lead to dangerous, potentially fatal, clotting or bleeding events. While a plethora of research tools and clinical therapies exist to control clot formation, options for controlling clot degradation are extremely limited. RNA and lipid-based technologies can be applied to the field of hematology and meet the need for long-acting agents to control the stability of clots. This work developed siRNA-LNP agents that increase or decrease the durability of clots in three model species, enabling further investigation of this pathway as a target for research in a wide range of coagulation disorders.
Monday, September 19, 2022 at 2:30 pm – 3:30 pm via Zoom
Hosted by: Dr. Christian Kastrup