“Host and Viral Determinants of Viral RNA Accumulation: from Hepatitis C Virus to Zika Virus”, Selena Sagan, Assistant Professor, McGill University.
Hepatitis C virus (HCV) and Zika virus (ZIKV) represent a significant threat to global health. As positive-sense RNA viruses, their viral genome itself must serve as a template for viral translation, replication, and packaging. However, how these viruses coordinate and regulate uses state-of-the-art approaches to study RNA-RNA and protein-RNA interactions important to the life cycle of these viruses. We aim to understand: Which regions of the genome mediate these events? How are these events regulated? What host/viral factors are involved? How can we interrogate these protein-RNA and RNA-RNA interactions on a genome-wide scale? How can we interfere with these processes? What can this teach us about cellular RNA regulation? This research will further our understanding of viral RNA accumulation, host-virus interactions, novel mechanisms of RNA regulation, and may provide new avenues for antiviral intervention for these important human pathogens
Hosted by Dr. Eric Jan
Thursday, May 25, 2017 at 10:00 am, LSC#3, 2350 Health Sciences Mall.