BMBDG Seminar: Ph.D. Exit Seminar – Karlton Scheu
Title: Dissecting the biophysical properties and DNA-binding specificity of the ETV6 transcription factor Abstract: Transcription factors bind to specific DNA sequences and regulate the expression of associated genes. In this thesis, I used several biophysical methods to investigate the structure and DNA-binding specificity profile of the eukaryotic transcription factor ETV6. I investigated the mechanisms by which ETV6 selectively […]
BMBDG Seminar: Ph.D. Exit Seminar – Enoli de Silva
Title: The role of the actin cytoskeleton in regulating platelet lifespan and function Abstract: Platelets are small discoid blood cells that regulate hemostasis and wound healing. Normal platelet function is largely contingent on the shape change reaction that occurs following the cells’ exposure to external stimuli and/or soluble agonists. Agonist-driven platelet shape change is mediated by reorganizations […]
BMBDG Seminar: Ph.D. Exit Seminar – John Chen
Title: Mutational scanning of metallo-β-lactamases to probe functional determinants, selection pressure dependence and homolog incompatibilities Abstract: Enzymes known as metallo-β-lactamases (MBLs) are a major source of bacterial resistance against β-lactams, one of the most widely used classes of clinical antibiotics. MBLs degrade almost all classes of β-lactams with high efficacy, and can be transmitted on plasmids. Detailed […]
BMBDG Seminar: Ph.D. Exit Seminar – Bronwyn Lyons
Posted on March 31, 2022 Title: Structural investigation of the Enteropathogenic Escherichia coli type 3 secretion system. Abstract: “Enteropathogenic Escherichia coli (EPEC) is frequently a cause of diarrheal disease, stemming from produce contamination due to farm waste run-offs, and inadequate supply of clean water. Virulence mechanisms that these bacteria employ to cause disease are conserved across many pathogens, such as […]
BMBDG Seminar: Ph.D. Exit Seminar – James Li
Title: Heterologous production and functional characterization of Auxiliary Activity family 10 lytic polysaccharide monooxygenases for fiber functionalization Abstract: “Organic matter from plants and animals (biomass) represents a largely untapped renewable resource. Cellulose and chitin are carbohydrate polymers that account for the majority of biomass found on earth and can be used to produce fuels, chemicals, […]
BMBDG Seminar: PhD Exit Seminar – David Rattray
Title: Proteomic Method Development for Studying Salmonella-Host Protein Interactions. Salmonella is a pathogen of humans and animals. Pathogenesis is mediated by effector proteins that are translocated into host cells. These effector proteins interact with host proteins and cellular processes to establish a replication permissive niche for the bacterium. Efforts to determine the roles of the effector proteins […]