Eric Wong – Doctoral Exam

“Prediction and Characterization of Protein-Protein Interfaces that Bind Intrinsically Disordered Protein Regions”, by Eric Wong, doctoral candidate, Gsponer Lab.

Thursday, November 28, 2019 12:30-3:30 pm, Room 203, Graduate Student Centre, 6371 Crescent Road.


Protein–protein interactions mediated by intrinsically disordered regions (IDRs) are differentiated from classical interactions between folded domains in terms of structure and function. Therefore, we developed a computational method specifically for the prediction of IDR-binding sites on the structures of folded domains. I will also discuss characteristics of IDR interactions, including localization patterns of disease and benign mutations that highlight the functional importance of IDR interactions.