• Categories: BMBDG Seminars

“Development of Biochemical Approaches to Study Siglec-Glycan Interactions”, by Mathew Macauley, Assistant Professor, Department of Chemistry, University of Alberta. Siglecs are a family of carbohydrate (glycan) binding proteins expressed on white blood cells that have immunomodulatory properties. Siglec-glycan interactions help maintain immune homeostasis and dysregulation of Siglec-glycan interactions have recently been implicated in cancer, neurodegeneration, […]

• Categories: BMBDG Seminars

“Sexual Interactions Induce Early Death in Nematodes: Strategies and Counterstrategies,” by Dr. Lauren N. Booth, Department of Genetics, Stanford. Sexual interactions can dramatically influence health, but the molecular mechanism is poorly understood because the sexes are typically kept separate in biomedical research. In C. elegans and its relatives, interactions between the sexes negatively impact health. […]

• Categories: BMBDG Seminars

“Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex,” by Dr. Monica C. Pillon, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, NIH Ribosome assembly is a complex process reliant on the coordination of trans-acting enzymes to produce functional ribosomal subunits and secure the translational capacity of the cell. Las1 is a […]

• Categories: BMBDG Seminars

“Evolved Molecules: Discovery and Directed Evolution of Nature’s Antibiotic Arsenal,” by Dr. Chad W. Johnson, Department of Biological Engineering, Massachusetts Institute of Technology. Antibiotics are essential components of modern medicine, but the overuse of broad-spectrum drugs and the emergence of drug-resistant pathogens have led to a looming crisis for global healthcare. Nearly all of our […]

• Categories: BMBDG Seminars

“Dissecting mechanisms that govern cellular plasticity, ”  by Dr. Bruno Di Stefano, MGH Department of Molecular Biology, Harvard Medical School. Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in regulating stem cell potency and cell fate transitions remain largely unexplored. We have recently identified the RNA processing protein […]

• Categories: BMBDG Seminars

“Genome folding in development, ” by Alistair Boettiger, Assistant Professor, Stanford School of Medicine, Department of Developmental Biology, Member of Stanford Bio-X, Member of Stanford Biophysics, Stanford University. Establishment of different cell types during development requires precise interactions between genes and distal regulatory elements. However, our understanding of what these interactions look like in three […]

• Categories: BMBDG Seminars

“Dynamic determinants for co-transcriptional gene regulation,” by Dr. Ana Fiszbien, Department of Biology, Massachusetts Institute of Technology. The architecture of mammalian genes enables the production of multiple transcripts that greatly expand the coding capacity of our genomes. Impacts of RNA processing on the stability of RNAs are known, but effects on transcription are less understood. […]

• Categories: BMBDG Seminars

“Tumor cells highjack diverse cellular  processes to maintain redox balance”, by Poul Sorensen, Professor, Department of Pathology & Laboratory Medicine, UBC, Distinguished Scientist, BC Cancer Research Centre Johal Chair in Childhood Cancer Research, UBC. In aggressive sarcomas such as Ewing sarcoma (EwS) and osteosarcoma (OS), the single-most powerful predictor of poor outcome is metastatic disease, […]

• Categories: BMBDG Seminars

Cancelled: “New modalities for interfering with outer membrane biogenesis in Gram-negative bacteria,”  by Steven Rutherford, Senior Scientist, Infectious Diseases, Genentech. Multi-drug resistant bacteria are a global health threat and new strategies are needed to combat them. However, the discovery of novel antibiotics to treat infections by Gram-negative bacteria has been thwarted by the outer membrane, […]

• Categories: BMBDG Seminars

“Method Development for High Throughput Biology,” by Nicolas Coutin, doctoral candidate, Corey Nislow Lab. Monday, March 16, 2020 at 4:00 pm, Room 200, Graduate Student Centre, 6371 Crescent Road