Lallous, Nada

Research Interests

My research interests focus on :

1. Elucidating basic mechanisms of transcriptional regulation
2. Elucidating the role of transcriptional condensates in cancer.
3. Combining biochemical, cellular, biophysical, and structural approaches to better understand the mechanism of actions of drugs of interest and their resistance mechanisms.

Publications

Comprehensive list

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Selected Publications

Dynamic phase separation of the androgen receptor and its coactivators key to regulate gene expression.

Zhang F, Biswas M, Massah S, Lee J, Lingadahalli S, Wong S, Wells C, Foo J, Khan N, Morin H, Saxena N, Kung SHY, Sun B, Parra Nuñez AK, Sanchez C, Chan N, Ung L, Altıntaş UB, Bui JM, Wang Y, Fazli L, Oo HZ, Rennie PS, Lack NA, Cherkasov A, Gleave ME, Gsponer J, Lallous N.Nucleic Acids Res. 2023 Jan 11;51(1):99-116. doi: 10.1093/nar/gkac1158.PMID: 36535377

PurificationDB: database of purification conditions for proteins.

Garland O, Radaeva M, Pandey M, Cherkasov A, Lallous N.Database (Oxford). 2023 Apr 3;2023:baad016. doi: 10.1093/database/baad016.PMID: 37010519

A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma.

Ramos L, Truong S, Zhai B, Joshi J, Ghaidi F, Lizardo MM, Shyp T, Kung SHY, Rezakhanlou AM, Oo HZ, Adomat H, Le Bihan S, Collins C, Bacha J, Brown D, Langlands J, Shen W, Lallous N, Sorensen PH, Daugaard M.Clin Cancer Res. 2023 Sep 1;29(17):3541-3553. doi: 10.1158/1078-0432.CCR-22-3897

Evaluation of Darolutamide (ODM201) Efficiency on Androgen Receptor Mutants Reported to Date in Prostate Cancer Patients.

Lallous N, Snow O, Sanchez C, Parra Nuñez AK, Sun B, Hussain A, Lee J, Morin H, Leblanc E, Gleave ME, Cherkasov A.Cancers (Basel). 2021 Jun 11;13(12):2939. doi: 10.3390/cancers13122939.PMID: 34208290

Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.

Lallous N, Volik SV, Awrey S, Leblanc E, Tse R, Murillo J, Singh K, Azad AA, Wyatt AW, LeBihan S, Chi KN, Gleave ME, Rennie PS, Collins CC, Cherkasov A.Genome Biol. 2016 Jan 26;17:10. doi: 10.1186/s13059-015-0864-1.PMID: 26813233