“Structure, mechanism, engineering and application of targeted nucleases for genome engineering,” by Barry Stoddard, Full Member, Fred Hutchinson Cancer Research Center, Basic Sciences Division. Monday, March 16, 2015 @ 3:00 pm, LSC #3, 2350 Health Sciences Mall.
BMBDG Seminar – Barry Stoddard
Maria de Lordes Vallejo Espi – Doctoral Exam
Thesis title, “Characterization of the mechanisms by which CAIX facilitates tumour growth and metastasis” by Maria de Lourdes Vallejo Espi. Tuesday, March 24, 2015 at 12:30 pm in Room 203, Graduate Student Centre, 6371 Crescent Road
BMBDG Seminar – David Westaway
“The Secret Life of Cellular Prion Proteins,” David Westaway, Professor and Director, Centre for Prions and Protein Folding Diseases, University of Alberta. Friday, February 13, 2015 @ 2:00 pm, Michael Smith Labs, Room #102, 2185 East Mall, Vancouver, BC V6T 1Z4
BMBDG Seminar – Suzie Pun
“Targeted Biomaterials: Applications in Hemostasis, Immunomodulation and Gene Delivery”, by Suzie Pun, Professor, Department of Bioengineering, University of Washington. Monday, February 16, 2015 @ 3:00 pm, LSC #3, 2350 Health Sciences Mall.
BMBDG Seminar- Andreas Martin
“Constructed to Deconstruct: ATP-fueled Molecular Machines for Protein Degradation”, Dr. Andreas Martin, Assistant Professor, Department of Molecular & Cell Biology, University of California, Berkeley. Monday, February 23, 2015 @ 3:00 pm, LSC #3, 2350 Health Sciences Mall.
CPS & BMB Joint Seminar – John E Burke
“Defining the molecular basis of phosphoinositide kinases regulation, and their role in disease using an integrated biophysical approach,” by John E. Burke, Assistant Professor, Department of Biochemistry and Microbiology, University of Victoria. Thursday, February 5, 2015 @ 12:30 pm, LSC #3, 2350 Health Sciences Mall.
Lipid phosphoinositides are essential regulators of many cellular processes, including growth, proliferation, membrane trafficking, and cytokinesis. The enzymes that modify these species are frequently misregulated in numerous human diseases. This is emphasised by the fact that one of the most frequently mutated genes in human cancer is the gene for phosphoinositide 3 kinase alpha (PIK3CA). I will discuss our work examining the regulation of phosphoinositide 3 kinases and phosphatidylinositol 4 kinases , and the molecular basis of how disease linked mutations modify their regulation. A specific focus will be on our synergy of X-ray crystallography, Hydrogen deuterium exchange mass spectrometry (HDX-MS), and functional biochemical assays to probe enzyme structure, dynamics, and function. These enzymes all act on membrane surfaces, and I will also focus on our development of novel biophysical tools to examine membrane signalling complexes in their native lipid environment.
Spence Macdonald – Completed MSc Thesis
Congratulations Spence! In December, Spence successfully defended his MSc thesis, ”A metagenomic search for glycoside phosphorylases using a phosphate dependent 2, 4-dinitrophenyl glycoside colorimetirc assay ” Spence studied in Dr. Withers’ lab.
Genevieve Desjardins – Doctoral Exam
Thesis title, “Structural characterization of DNA binding and auto-inhibition in the Ets1 transcription factor” by Genevieve Desjardins. Revised: Thursday, March 5, 2015 at 12:30 pm in Room 1510, Life Sciences Centre, 2350 Health Sciences Mall.
BMBDG Seminar – Peter Stirling
“DNA:RNA hybrids and genome instability”, by Peter Stirling, Assistant Professor, BC Cancer Agency, Terry Fox Lab, UBC. Monday, January 26, 2015 @ 3:00 pm, LSC #3, 2350 Health Sciences Mall.
BMBDG Seminar – Steve Hahn
“Mechanisms of RNA polymerase II transcription initiation and activation”, by Steve Hahn, Division of Basic Sciences, Fred Hutchinson Cancer Research Center. Wednesday, January 28, 2015 @ 4:00 pm, LSC #3, 2350 Health Sciences Mall.